Symptom perception, placebo effects, and the Bayesian brain

Artigo na íntegra sobre um tema muito interessante e que ilustra uma mudança de paradigma do modelo biomédico, na interpretação do efeito placebo e nocebo. Tanto um como outro são respostas de um sistema nervoso central ativo e são uma parte integrante na cura e nos sintomas do paciente. Entender estes importantes mecanismos e torná-los inclusivos na terapêutica e prognóstico (em vez de os considerar como uma resposta aberrante) é uma mudança de paradigma.

Boa leitura !

Symptom perception, placebo effects, and the Bayesian brain

Giulio Ongaroa, Ted J. Kaptchukb

"...Conclusion: Symptoms without a physical cause and relief through placebo intervention are anomalies for the biomedical model of disease. The Bayesian approach to perception explains and accommodates these 2 phenomena. It exposes placebo and nocebo effects, not as aberrant events, but as facets of the overall modus operandi of the nervous system. It shows, also, that these act on the same inferential processes as “real” disease and “real” treatments do. The implication of this approach is that, to be truly patient-focused, medicine must attend to the predictive process that lies at the basis of symptom perception, and thereupon evaluate what efficient courses of action can lead the brain to predict the body’s health."

3http://eprints.lse.ac.uk/90458/1/Ongaro_Symptom%20perception_2018.pdf